Three patients (one female and two males) with Prader-Willi Syndrome (PWS) due to a micro-deletion on chromosome 15p have received a Roux-en-Y gastric bypass (RYGB) in Adelaide since May 2013. Length of follow up is between 3 years and 6 months with two being greater than 2 years.
The first patient was a female (age 40, BMI 55.2kg/m2) who had obstructive sleep apnoea (OSA) and central sleep apnoea (treated with BiPap), type 2 diabetes mellitus (T2DM) (treated orally with Metformin), hypogonadism (treated with topical testosterone) and chronic lower limb oedema. The second patient a male (age 30; BMI 46.7kg/m2) had poorly controlled T2DM, OSA, and chronic lower limb oedema with recurrent ulceration and infection. The third patient, a male (age 22, BMI 47.7 kg/ m2) had hypogonadism (treated with topical ).
|
Patient |
Pre surgery |
|
|
12 months |
Post |
Surgery* |
|
|
Weight (kg) |
Height (cm) |
BMI (kg/m2) |
Weight (kg) |
Height (cm) |
BMI (kg/m2) |
|
1 |
116 |
145 |
45 |
82 |
145 |
39 |
|
2 |
121 |
161 |
46.7 |
74 |
161 |
28 |
|
3 |
119 |
157 |
48.3 |
102 |
157 |
41.7 |
*Patient 3 data is 4 months post surgery
All patients have shown a marked decrease in leg oedema, much improved diabetes control (patients 1 and 2) and self-reported improvements in satiation. Bariatric surgery is not currently considered a treatment for PWS however the degree of success seen within these patients should allow for national trial.