Introduction: Studies showed that some individuals express weaker satiety efficiency, and thus, may be more susceptible to weight gain or weight loss resistance. This study aimed to evaluate the impact of a weight-loss program on eating behaviour traits in individuals with different satiety efficiency. Methods: A pooled cohort of obese individuals (n=100; aged 38.7±8.7 years) who participated in a 12-16 wk weight-loss program targeting an energy deficit of 500-700 kcal/d were included in this study. The satiety efficiency was determined by median split of mean satiety quotients based on appetite sensations measured in response to a test meal at baseline. Anthropometric variables, eating behaviour traits (TFEQ) and ad libitum energy intake (EI) (buffet) were assessed before and after the intervention. Results: Similar weight loss was observed between low and normal/high satiety efficiency groups (-3.5±3.2 vs -3.8±2.9, p=0.64). ANOVAs (adjusted for initial weight and behaviour) showed time by group interactions for cognitive restraint, flexible control (FC), strategic dieting behaviour (STB), avoidance of fattening foods (AFF) and situational disinhibition (SD) (0.02 ≥ p ≤ 0.01). T-tests showed that individuals with low satiety efficiency experienced a higher increase in cognitive restraint (5.5±4.1 vs. 3.5±3.5, p=0.016), FC (2.5±2.1 vs. 1.6±1.3, p=0.019), SDB (1.6±1.5 vs. 0.9±1.5, p=0.02), AFF (1.0±1.2 vs. 0.4±1.0, p=0.015) and a lower decrease in SD (-0.7±1.1 vs. -1.2±1.3, p=0.02) after the intervention compared to the normal/high satiety efficiency group. Moreover, individuals with lower satiety efficiency had a higher EI at the buffet meal after the intervention compared to the normal/high satiety efficiency group (920±323 vs. 788±291 kcal, p=0.036). Conclusion: This study suggests that energy restriction could have an undesirable impact on eating behaviour traits and energy intake in individuals experiencing lower satiety efficiency. Other studies should evaluate if these changes could increase their susceptibility to weight regain.